They demonstrated efficacy of the novel vaccine candidates and durability of the immune responses in animal models.
Results, published in the Journal of Infectious Diseases, showed strong immune responses one year after the last dose, supporting the long-term immunogenicity of the vaccine -- a particularly challenging area for Ebola vaccines.
"The success of intradermal delivery of a low-dose regimen is very encouraging. The ultimate goal of our work is to create effective and safe vaccines that are optimised for field use in at-risk areas," said Ami Patel from The Wistar Institute.
The researchers optimised a shorter, dose-sparing, immunisation regimen and simplified vaccine administration directly into the skin.
This new approach induced rapid and protective immunity from virus challenges.
The detected antibody levels were equal or higher to those reported for other vaccines currently being evaluated in the clinic, according to the study.
"Synthetic non-viral based DNA technology allows for rapid vaccine development by delivery directly into the skin, resulting in consistent, potent and rapid immunity compared to traditional vaccine approaches," said David B Weiner from Wistar's Vaccine & Immunotherapy Center.
Recent advances have led to the development of promising experimental vaccine candidates that may be associated with side effects and may not be applicable in specific vulnerable populations, such as children, pregnant women and immunocompromised individuals.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)
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1 September 2018
1 September 2018